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1

Design and Synthesis of Highly Potent and Isoform Selective JNK3 Inhibitors: SAR Studies on Aminopyrazole Derivatives

Zheng, Ke, Iqbal, Sarah, Hernandez, Pamela, Park, HaJeung, LoGrasso, Philip V., Feng, Yangbo

Journal:

Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 3.99 MB

english, 2014

2

Crystal structure of dihydrodipicolinate reductase (PaDHDPR) from Paenisporosarcina sp. TG-14: structural basis for NADPH preference as a cofactor

Lee, Chang Woo, Park, Sun-Ha, Lee, Sung Gu, Park, Hyun Ho, Kim, Hak Jun, Park, HaJeung, Park, Hyun, Lee, Jun Hyuck

Journal:

Scientific Reports

Year:

2018

Language:

english

File:

PDF, 6.01 MB

english, 2018

3

A Simple and Efficient System for Producing Recombinant Human CXCL8 in Escherichia coli

Huang, Changhao, Zhong, Shangwei, Park, HaJeung, Jeong, Ji-Hak, Luo, Jun-Li

Journal:

Journal of Interferon & Cytokine Research

Year:

2020

File:

PDF, 233 KB

2020

4

Structural insights into the psychrophilic germinal protease PaGPR and its autoinhibitory loop

Lee, Chang Woo, Lee, Saeyoung, Jeong, Chang-Sook, Hwang, Jisub, Chang, Jeong Ho, Choi, In-Geol, Kim, T. Doohun, Park, HaJeung, Kim, Hye-Yeon, Lee, Jun Hyuck

Journal:

Journal of Microbiology

Year:

2020

File:

PDF, 723 KB

2020

5

A Dynamic Structural Model of Expanded RNA CAG Repeats: A Refined X-ray Structure and Computational Investigations Using Molecular Dynamics and Umbrella Sampling Simulations

Yildirim, Ilyas, Park, HaJeung, Disney, Matthew D., Schatz, George C.

Journal:

Journal of the American Chemical Society

Year:

2013

Language:

english

File:

PDF, 1.62 MB

english, 2013

6

Correction to Design and Synthesis of Highly Potent and Isoform Selective JNK3 Inhibitors: SAR Studies on Aminopyrazole Derivatives

Zheng, Ke, Iqbal, Sarah, Hernandez, Pamela, Park, HaJeung, LoGrasso, Philip V., Feng, Yangbo

Journal:

Journal of Medicinal Chemistry

Year:

2016

File:

PDF, 166 KB

2016

7

Molecular Mechanisms of Host Cytoskeletal Rearrangements by Shigella Invasins

Lee, Jun, Park, HaJeung, Park, Yong

Journal:

International Journal of Molecular Sciences

Year:

2014

Language:

english

File:

PDF, 2.30 MB

english, 2014

8

Amino acid derived quinazolines as Rock/PKA inhibitors

Chowdhury, Sarwat, Chen, Yen Ting, Fang, Xingang, Grant, Wayne, Pocas, Jennifer, Cameron, Michael D., Ruiz, Claudia, Lin, Li, Park, HaJeung, Schröter, Thomas, Bannister, Thomas D., LoGrasso, Philip V.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 2.68 MB

english, 2013

9

Crystal structure of UbiX, an aromatic acid decarboxylase from the psychrophilic bacterium Colwellia psychrerythraea that undergoes FMN-induced conformational changes

Do, Hackwon, Kim, Soo Jin, Lee, Chang Woo, Kim, Han-Woo, Park, Hyun Ho, Kim, Ho Min, Park, Hyun, Park, HaJeung, Lee, Jun Hyuck

Journal:

Scientific Reports

Year:

2015

Language:

english

File:

PDF, 2.80 MB

english, 2015

10

Structural Basis and Biological Consequences for JNK2/3 Isoform Selective Aminopyrazoles

Park, HaJeung, Iqbal, Sarah, Hernandez, Pamela, Mora, Rudy, Zheng, Ke, Feng, Yangbo, LoGrasso, Philip

Journal:

Scientific Reports

Year:

2015

Language:

english

File:

PDF, 1.54 MB

english, 2015

11

Crystal structure and modeling of the tetrahedral intermediate state of methylmalonate-semialdehyde dehydrogenase (MMSDH) fromOceanimonas doudoroffii

Do, Hackwon, Lee, Chang Woo, Lee, Sung Gu, Kang, Hara, Park, Chul Min, Kim, Hak Jun, Park, Hyun, Park, HaJeung, Lee, Jun Hyuck

Journal:

Journal of Microbiology

Year:

2016

Language:

english

File:

PDF, 961 KB

english, 2016

12

Structural Characterization of a Peptoid-Inspired Conformationally Constrained Oligomer (PICCO) Bound To Streptavidin

McEnaney, Patrick, Blalzarini, Madeline, Park, HaJeung, Kodadek, Thomas

Journal:

Chemical Communications

Year:

2020

File:

PDF, 1.24 MB

2020

13

Controlled dehydration improves the diffraction quality of two RNA crystals

Park, HaJeung, Tran, Tuan, Lee, Jun Hyuck, Park, Hyun, Disney, Matthew D.

Journal:

BMC Structural Biology

Year:

2016

Language:

english

File:

PDF, 1.79 MB

english, 2016

14

Crystallographic and Computational Analyses of AUUCU Repeating RNA That Causes Spinocerebellar Ataxia Type 10 (SCA10)

Park, HaJeung, González, Àlex L., Yildirim, Ilyas, Tran, Tuan, Lohman, Jeremy R., Fang, Pengfei, Guo, Min, Disney, Matthew D.

Journal:

Year:

2015

Language:

english

File:

PDF, 1.81 MB

english, 2015

15

The structural flexibility of the shank1 PDZ domain is important for its binding to different ligands

Jun Hyuck Lee, HaJeung Park, Soo Jeong Park, Hak Jun Kim, Soo Hyun Eom

Journal:

Biochemical and Biophysical Research Communications

Year:

2011

Language:

english

File:

PDF, 1007 KB

english, 2011

16

Discovery of Novel Small Molecule Inhibitors of LIM Domain Kinase for Inhibiting HIV-1

Yi, Fei, Guo, Jia, Dabbagh, Deemah, Spear, Mark, He, Sijia, Kehn-Hall, Kylene, Fontenot, Jacque, Yin, Yan, Bibian, Mathieu, Park, Chul Min, Zheng, Ke, Park, HaJeung, Soloveva, Veronica, Gharaibeh, Dim

Journal:

Journal of Virology

Year:

2017

Language:

english

File:

PDF, 1.98 MB

english, 2017

17

Synthesis and Biological Evaluation of Urea Derivatives as Highly Potent and Selective Rho Kinase Inhibitors

Yin, Yan, Lin, Li, Ruiz, Claudia, Khan, Susan, Cameron, Michael D., Grant, Wayne, Pocas, Jennifer, Eid, Nibal, Park, HaJeung, Schröter, Thomas, LoGrasso, Philip V., Feng, Yangbo

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 2.96 MB

english, 2013

18

Induction and reversal of myotonic dystrophy type 1 pre-mRNA splicing defects by small molecules

Childs-Disney, Jessica L., Stepniak-Konieczna, Ewa, Tran, Tuan, Yildirim, Ilyas, Park, HaJeung, Chen, Catherine Z., Hoskins, Jason, Southall, Noel, Marugan, Juan J., Patnaik, Samarjit, Zheng, Wei, Aus

Journal:

Nature Communications

Year:

2013

Language:

english

File:

PDF, 1.36 MB

english, 2013

19

Bis-aryl Urea Derivatives as Potent and Selective LIM Kinase (Limk) Inhibitors

Yin, Yan, Zheng, Ke, Eid, Nibal, Howard, Shannon, Jeong, Ji-Hak, Yi, Fei, Guo, Jia, Park, Chul Min, Bibian, Mathieu, Wu, Weilin, Hernandez, Pamela, Park, HaJeung, Wu, Yuntao, Luo, Jun-Li, LoGrasso, Ph

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 3.46 MB

english, 2015

20

Structural studies of Streptococcus pneumoniae EPSP synthase in unliganded state, tetrahedral intermediate-bound state and S3P-GLP-bound state

HaJeung Park, Jacqueline L. Hilsenbeck, Hak Jun Kim, Wendy A. Shuttleworth, Yong Ho Park, Jeremy N. Evans, ChulHee Kang

Journal:

Molecular Microbiology

Year:

2004

Language:

english

File:

PDF, 571 KB

english, 2004

21

A Toxic RNA Catalyzes the In Cellulo Synthesis of Its Own Inhibitor

Rzuczek, Suzanne G., Park, HaJeung, Disney, Matthew D.

Journal:

Angewandte Chemie

Year:

2014

Language:

english

File:

PDF, 1.23 MB

english, 2014

22

Pharmacological repression of PPARγ promotes osteogenesis

Marciano, David P., Kuruvilla, Dana S., Boregowda, Siddaraju V., Asteian, Alice, Hughes, Travis S., Garcia-Ordonez, Ruben, Corzo, Cesar A., Khan, Tanya M., Novick, Scott J., Park, HaJeung, Kojetin, Do

Journal:

Nature Communications

Year:

2015

Language:

english

File:

PDF, 650 KB

english, 2015

23

A Toxic RNA Catalyzes the In Cellulo Synthesis of Its Own Inhibitor

Rzuczek, Suzanne G., Park, HaJeung, Disney, Matthew D.

Journal:

Angewandte Chemie International Edition

Year:

2014

Language:

english

File:

PDF, 1.56 MB

english, 2014

24

Crystal structure of the inactive state of the receiver domain of Spo0A fromPaenisporosarcinasp. TG-14, a psychrophilic bacterium isolated from an Antarctic glacier

Lee, Chang Woo, Park, Sun-Ha, Lee, Sung Gu, Shin, Seung Chul, Han, Se Jong, Kim, Han-Woo, Park, Hyun Ho, Kim, Sunghwan, Kim, Hak Jun, Park, Hyun, Park, HaJeung, Lee, Jun Hyuck

Journal:

Journal of Microbiology

Year:

2017

Language:

english

File:

PDF, 967 KB

english, 2017

25

Bauerenol Acetate, the Pentacyclic Triterpenoid from Tabernaemontana longipes, is an Antitrypanosomal Agent

Carothers, Simira, Nyamwihura, Rogers, Collins, Jasmine, Zhang, Huaisheng, Park, HaJeung, Setzer, William, Ogungbe, Ifedayo

Journal:

Year:

2018

Language:

english

File:

PDF, 621 KB

english, 2018

26

Synthesis of Benzoquinone Ansamycin-Inspired Macrocyclic Lactams from Shikimic Acid

Jeso, Valer, Iqbal, Sarah, Hernandez, Pamela, Cameron, Michael D., Park, HaJeung, LoGrasso, Philip V., Micalizio, Glenn C.

Journal:

Angewandte Chemie International Edition

Year:

2013

Language:

english

File:

PDF, 961 KB

english, 2013

27

Synthesis of Benzoquinone Ansamycin-Inspired Macrocyclic Lactams from Shikimic Acid

Jeso, Valer, Iqbal, Sarah, Hernandez, Pamela, Cameron, Michael D., Park, HaJeung, LoGrasso, Philip V., Micalizio, Glenn C.

Journal:

Angewandte Chemie

Year:

2013

Language:

english

File:

PDF, 770 KB

english, 2013

28

Crystal structure of the cytotoxic bacterial protein colicin B at 2.5 Å resolution

Jacqueline L. Hilsenbeck, HaJeung Park, Gregory Chen, Buhyun Youn, Kathleen Postle, ChulHee Kang

Journal:

Molecular Microbiology

Year:

2004

Language:

english

File:

PDF, 492 KB

english, 2004

29

Myotonic Dystrophy Type 1 RNA Crystal Structures Reveal Heterogeneous 1 × 1 Nucleotide UU Internal Loop Conformations

Kumar, Amit, Park, HaJeung, Fang, Pengfei, Parkesh, Raman, Guo, Min, Nettles, Kendall W., Disney, Matthew D.

Journal:

Year:

2011

Language:

english

File:

PDF, 4.32 MB

english, 2011

30

Site-Selective Antibody Functionalization via Orthogonally Reactive Arginine and Lysine Residues

Hwang, Dobeen, Nilchan, Napon, Nanna, Alex R., Li, Xiaohai, Cameron, Michael D., Roush, William R., Park, HaJeung, Rader, Christoph

Journal:

Cell Chemical Biology

Year:

2019

Language:

english

File:

PDF, 3.26 MB

english, 2019

31

A Small Molecule Bidentate-Binding Dual Inhibitor Probe of the LRRK2 and JNK Kinases

Feng, Yangbo, Chambers, Jeremy W., Iqbal, Sarah, Koenig, Marcel, Park, HaJeung, Cherry, Lisa, Hernandez, Pamela, Figuera-Losada, Mariana, LoGrasso, Philip V.

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 2.92 MB

english, 2013

32

Corrigendum: A Toxic RNA Catalyzes the In Cellulo Synthesis of Its Own Inhibitor

Rzuczek, Suzanne G., Park, HaJeung, Disney, Matthew D.

Journal:

Angewandte Chemie International Edition

Year:

2016

File:

PDF, 328 KB

2016

33

Design, Optimization, and Study of Small Molecules That Target Tau Pre-mRNA and Affect Splicing

Chen, Jonathan L., Zhang, Peiyuan, Abe, Masahito, Aikawa, Haruo, Zhang, Liying, Frank, Alexander J., Zembryski, Timothy, Hubbs, Christopher, Park, HaJeung, Withka, Jane, Steppan, Claire, Rogers, Lucy,

Journal:

Journal of the American Chemical Society

Year:

2020

File:

PDF, 6.86 MB

2020

34

Structure of the Myotonic Dystrophy Type 2 RNA and Designed Small Molecules That Reduce Toxicity

Childs-Disney, Jessica L., Yildirim, Ilyas, Park, HaJeung, Lohman, Jeremy R., Guan, Lirui, Tran, Tuan, Sarkar, Partha, Schatz, George C., Disney, Matthew D.

Journal:

ACS Chemical Biology

Year:

2014

Language:

english

File:

PDF, 1.65 MB

english, 2014

35

Pyridopyrimidinone Derivatives as Potent and Selective c-Jun N-Terminal Kinase (JNK) Inhibitors

Zheng, Ke, Park, Chul Min, Iqbal, Sarah, Hernandez, Pamela, Park, HaJeung, LoGrasso, Philip V., Feng, Yangbo

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 1.39 MB

english, 2015

36

Berichtigung: A Toxic RNA Catalyzes the In Cellulo Synthesis of Its Own Inhibitor

Rzuczek, Suzanne G., Park, HaJeung, Disney, Matthew D.

Journal:

Angewandte Chemie

Year:

2016

File:

PDF, 311 KB

2016

37

Potent and selective antitumor activity of a T cell-engaging bispecific antibody targeting a membrane-proximal epitope of ROR1

Qi, Junpeng, Li, Xiuling, Peng, Haiyong, Cook, Erika M., Dadashian, Eman L., Wiestner, Adrian, Park, HaJeung, Rader, Christoph

Journal:

Proceedings of the National Academy of Sciences

Year:

2018

Language:

english

File:

PDF, 1.66 MB

english, 2018

38

A Crystal Structure of a Model of the Repeating r(CGG) Transcript Found in Fragile X Syndrome

Dr. Amit Kumar, Dr. Pengfei Fang, Dr. Hajeung Park, Prof. Dr. Min Guo, Prof. Dr. Kendall W. Nettles, Prof. Dr. Matthew D. Disney

Journal:

Year:

2011

Language:

english

File:

PDF, 1.25 MB

english, 2011

39

Discovery of Potent and Selective Covalent Inhibitors of JNK

Tinghu Zhang, Francisco Inesta-Vaquera, Mario Niepel, Jianming Zhang, Scott B. Ficarro, Thomas Machleidt, Ting Xie, Jarrod A. Marto, NamDoo Kim, Taebo Sim, John D. Laughlin, Hajeung Park, Philip V. Lo

Journal:

Chemistry & Biology

Year:

2012

Language:

english

File:

PDF, 1.31 MB

english, 2012

40

Shigella IpaA Binding to Talin Stimulates Filopodial Capture and Cell Adhesion

Valencia-Gallardo, Cesar, Bou-Nader, Charles, Aguilar-Salvador, Daniel-Isui, Carayol, Nathalie, Quenech’Du, Nicole, Pecqueur, Ludovic, Park, HaJeung, Fontecave, Marc, Izard, Tina, Tran Van Nhieu, Guy

Journal:

Year:

2019

File:

PDF, 3.88 MB

2019

41

Site-Specific Lysine Arylation as an Alternative Bioconjugation Strategy for Chemically Programmed Antibodies and Antibody–Drug Conjugates

Hwang, Dobeen, Tsuji, Kohei, Park, HaJeung, Burke, Terrence R., Rader, Christoph

Journal:

Bioconjugate Chemistry

Year:

2019

Language:

english

File:

PDF, 3.50 MB

english, 2019

42

Affinity maturation, humanization, and co-crystallization of a rabbit anti-human ROR2 monoclonal antibody for therapeutic applications

Goydel, Rebecca S., Weber, Justus, Peng, Haiyong, Qi, Junpeng, Soden, Jo, Freeth, Jim, Park, HaJeung, Rader, Christoph

Journal:

Journal of Biological Chemistry

Year:

2020

Language:

english

File:

PDF, 1012 KB

english, 2020

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